lunes, 30 de mayo de 2016

Avances sobre la infección con ZIKA





Artículo reciente del New England Journal of Medicine (16 de mayo ) que precisa la relación entre el virus ZIKA y los defectos congénitos del SNC en recién nacidos. 

Sonja A. Rasmussen, Denise J. Jamieson, Margaret A. Honein, Lyle R. Petersen. Zika Virus and Birth Defects — Reviewing the Evidence for Causality.  N Engl J Med 2016; 374:1981-1987 May 19, 2016DOI: 10.1056/NEJMsr1604338
On the basis of this review, we conclude that a causal relationship exists between prenatal Zika virus infection and microcephaly and other serious brain anomalies. Evidence that was used to support this causal relationship included Zika virus infection at times during prenatal development that were consistent with the defects observed; a specific, rare phenotype involving microcephaly and associated brain anomalies in fetuses or infants with presumed or confirmed congenital Zika virus infection.
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Nuevos modelos experimentales en ratones, demuestran los mecanismos como el virus ZIKA infecta la placenta y el sistema nervioso del feto.

Cui Li, Dan Xu, Qing Ye, Shuai Hong, Yisheng Jiang, Xinyi Liu, Nana Zhang, Lei Shi, Cheng-Feng Qin, Zhiheng Xu. Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice. Cell Stem Cell, 2016; DOI: 10.1016/j.stem.2016.04.017
 
Jonathan J. Miner, Bin Cao, Jennifer Govero, Amber M. Smith, Estefania Fernandez, Omar H. Cabrera, Charise Garber, Michelle Noll, Robyn S. Klein, Kevin K. Noguchi, Indira U. Mysorekar, Michael S. Diamond. Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise. Cell, 2016; DOI: 10.1016/j.cell.2016.05.008

Maracaibo, 30 de mayo, 2016

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