Artículo reciente del New England Journal of Medicine (16 de mayo ) que
precisa la relación entre el virus ZIKA y los defectos congénitos del SNC en
recién nacidos.
Sonja A. Rasmussen, Denise J. Jamieson, Margaret
A. Honein, Lyle R. Petersen. Zika Virus and Birth Defects — Reviewing the Evidence for
Causality. N Engl J Med 2016; 374:1981-1987 May 19, 2016DOI:
10.1056/NEJMsr1604338
On the basis of this review, we conclude that
a causal relationship exists between prenatal Zika virus infection and
microcephaly and other serious brain anomalies. Evidence that was used to support this causal
relationship included Zika virus infection at times during prenatal development
that were consistent with the defects observed; a specific, rare phenotype involving microcephaly and associated brain
anomalies in fetuses or infants with presumed or confirmed congenital Zika
virus infection.
……………………………………………………………………………………………………………
Nuevos modelos
experimentales en ratones, demuestran los mecanismos como el virus ZIKA infecta
la placenta y el sistema nervioso del feto.
Cui Li, Dan Xu, Qing Ye, Shuai Hong, Yisheng Jiang, Xinyi Liu, Nana
Zhang, Lei Shi, Cheng-Feng Qin, Zhiheng Xu. Zika Virus
Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice. Cell Stem Cell, 2016; DOI: 10.1016/j.stem.2016.04.017
Jonathan J. Miner, Bin Cao, Jennifer Govero,
Amber M. Smith, Estefania Fernandez, Omar H. Cabrera, Charise Garber, Michelle
Noll, Robyn S. Klein, Kevin K. Noguchi, Indira U. Mysorekar, Michael S.
Diamond. Zika Virus Infection during Pregnancy in Mice
Causes Placental Damage and Fetal Demise. Cell, 2016; DOI: 10.1016/j.cell.2016.05.008
Maracaibo, 30 de mayo, 2016
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